In the News

Genetic Engineering & Biotechnology News: Tau Tangles Cleared by Senolytic Drugs in Alzheimer’s Mice

August 23, 2018

Tangles of tau protein in the brain constitute a hallmark of Alzheimer’s disease, but exactly how these tangles exert their toxic effects remains poorly understood. In hopes of untangling tau’s mysteries, scientists based at the UT Health San Antonio delved into postmortem brain tissue from Alzheimer’s patients and generated transcriptomic profiles. These profiles revealed expression […]

Comment about findings of the Alzheimer’s Disease Sequencing Project

August 17, 2018

Sudha Seshadri, M.D., professor of neurology at UT Health San Antonio and founding director of the university’s Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases, made the following statement about the Alzheimer’s Disease Sequencing Project, findings of which were announced Tuesday, Aug. 14. Dr. Seshadri is principal investigator of the research, which was developed jointly by [...]

Abnormal gene copying seen in tauopathy fruit fly models

July 23, 2018

It sounds like science fiction: Nefarious genes clone themselves and settle their rogue copies in distant outposts of the galaxy (namely, our DNA), causing disease. But it’s a real phenomenon, and in research published July 23, scientists at UT Health San Antonio revealed that this genetic copy-and-paste activity is significantly increased in fruit fly models […]

Biggs researcher awarded UT System STARs award

July 9, 2018

Xianlin Han, Ph.D., professor in the Department of Medicine, the Sam and Ann Barshop Institute for Longevity and Aging Studies and the Biggs Institute for Alzheimer’s & Neurodegenerative Diseases has received a $300,000 STARs award from the UT System. Dr. Han’s laboratory focuses on lipidomics, a relatively new field of biomedical research which involves complex lipidome […]

Dementia and genes to be discussed

June 7, 2018

Dementia, a decline in mental ability that is severe enough to interfere with the activities of daily life, is not the result of a single mutation in a single gene, said Sudha Seshadri, M.D., professor and founding director of the Glenn Biggs Institute for Alzheimer’s & Neurodegenerative Diseases at UT Health San Antonio. On the […]

Dementia Trend Shows Later Onset with Fewer Years of the Disease

April 23, 2018

The diagnosis is one that a family never wants to hear: Your father has Alzheimer’s disease. Your mother has stroke-related dementia. Sudha Seshadri, M.D., professor of neurology and founding director of the Glenn Biggs Institute for Alzheimer’s & Neurodegenerative Diseases at UT Health San Antonio, is the senior author on the study, which draws evidence from the […]

Study reveals novel biomarkers for future dementia risk

March 7, 2018

Participants’ blood samples were drawn years before their dementia diagnosis. Sudha Seshadri, M.D., founding director of the Glenn Biggs Institute for Alzheimer’s & Neurodegenerative Diseases at UT Health San Antonio, is co-leader and senior author on research announced March 6 that identifies novel biomarkers of risk for future dementia. Dementia is a rising tidal wave […]