Research Team Members

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Qitao Ran, Ph.D.

Research surrounds the exploration of mitochondria. Mitochondria are organelles with multiple functions essential for neural activities and the dysfunction of which is implicated in the pathogenesis of Alzheimer’s disease, especially for sporadic and late-onset cases. Research focuses to illustrate the underlying mechanisms of mitochondrial dysfunction in relation to Alzheimer’s disease and aging, with a goal of identifying novel targets for prevention and treatment of the disease.

Research Areas
Biological & Innovative Research

Contact:
Ran@uthscsa.edu
Research Profile

Claudia L. Satizabal, Ph.D.

Interests are centered on the lifestyle and genetic determinants influencing abnormal brain aging (cerebrovascular and neurodegenerative neuroimaging markers), stroke, cognitive decline and dementia. Ongoing research is focused on the impact of midlife obesity on the risk of late-onset Alzheimer’s Disease and related endophenotypes, the association between fatty acids and the risk of stroke and understanding the relationship between mitochondrial DNA features and age-related diseases, including Alzheimer’s Disease. Actively involved in the Neurology and Cognitive working groups of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium, leading projects investigating the genetic determinants of subcortical brain structures fine motor speed and visual memory. Other collaborations, include the Trans-Omics for Precision Medicine (TOPMed), the Alzheimer’s Disease Sequencing Project (ADSP) and the Markers for Vascular Contributions to Cognitive Impairment and Dementia (MarkVCID).

Research Areas
Population Neuroscience

Contact:
satizabal@uthscsa.edu
Research Profile

Sudha Seshadri, M.D., D.M.

Dr. Seshadri is a senior investigator of the Framingham Heart Study since 1998, leading the study’s clinical neurology and neurogenesis cores since 2005. She is the principal investigator on 8 NIH funded grants and is an investigator, subcontract principal investigator and consultant to 12 additional grants. She has served on the Editorial Board for Neurology and Stroke, chaired a standing NIH Study Section (Neurology, Aging and Musculoskeletal Epidemiology) and has over 320 peer-reviewed publications (H-index 79, i10 index 209), including 57 in 2016. Dr. Seshadri helped to establish the neurology phenotype working group within the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. She lectures extensively, nationally and internationally, on Alzheimer’s disease, dementia and the genetics of stroke and vascular brain injury.

Research Areas
Biological & Innovative Research, Clinical Research

Contact:
Research Profile

Meghan Short, Ph.D.

Meghan Short, Ph.D., is a biostatistician and bioinformatician. Dr. Short’s research interests involve the use and integration of omics data to understand complex biological underpinnings of Alzheimer’s Disease and brain aging. Current and proposed projects include identifying networks of proteins in the plasma proteome in older adults and relating them to brain MRI measures and incident dementia, and examining changes in the gut microbiome related to neurodegeneration. She has also been a statistical analyst for a range of epidemiological studies of cardiovascular risk factors and has developed statistical methods for clinical trials and epidemiological studies with clustered binary outcomes.

Research Areas
Biological & Innovative Research, Population Neuroscience