Pre-Meeting Working Groups at Hotel Contessa

2:00–5:00 PM | Global Alliance Outcomes | River Level, Cypress Meeting Room
Arne Lindgren, MD, PhD

3:00–5:00 PM | Early Onset Stroke Group Joint Session with Global Alliance | River Level, Cypress Meeting Room

4:00–5:00 PM | IA Working Group | Street Level, Palm Meeting Room

6:00 PM | Steering Committee Dinner

8:00 AM | Conference Check-In Opens | Hotel Contessa, Second-Floor, Ballroom

Attendees are welcome to enjoy a continental breakfast featuring freshly brewed coffee and a selection of hot teas, available in the foyer.

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8:30 AM | Welcome and Opening Remarks | Sudha Seshadri, MD, and Muralidharan Sargurupremraj, PhD, UT Health San Antonio

Introduction to the ISGC | Amy Brodtmann, MBBS, PRACP, PhD, FANZAN, Monash University, and Brad Worrall, MD, MSc, the University of Virginia

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Keynote Lecture 1

8:45 AM | Stroke Genomics: From Discovery to Clinical Translation | Stéphanie Debette, MD, Paris Brain Institute

9:15 AM | Dissecting Alzheimer’s Disease with Single-Cell Multi-Omics, Causal Representation Learning and xQTL Analysis | Zhongming Zhao, PhD, MS, UTHealth Houston

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Session 1: Genetic Architecture of Stroke and Its Subtypes 

9:55 AM |TERASTROKE GWAS: Consortium Update | Rainer Malik, PhD, LMU Munich,Stéphanie Debette, Martin Dichgans, MD, University of Munich

10:15 AM | Genetic Underpinnings of Stroke in Hispanic/Latino Populations | Yao Tu, PhD, Penn State University

10:30 AM | Modifying Effects of Polygenic Risk Scores in Monogenic Cerebral Small Vessel Disease | Shiyao Cheng, MPH, Paris Brain Institute

10:45 AM | Panel Discussion and Q&A

11:00 AM | Break: Morning refreshments and snacks will be available in the foyer.

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Session 2: xQTL/pQTL and Drug-Target Discovery 

11:15 AM | Multi-Scale Genomic Triangulation of Druggable Targets for Neuroimaging Markers of cSVD Identifies Therapeutic Candidates and Pharmacogenomic Modifiers | Muralidharan Sargurupremraj, PhD, UT Health San Antonio

11:30 AM | Proteogenomic Integration Reveals Paralemmin-1 as a Mediator of Increased Intracerebral Hemorrhage Risk in APOE ε4 Carriers | Shufan Huo, MD, PhD, German Center For Neurodegenerative Diseases

11:45 AM | A Multi-Omics Tree-Based Framework for Clustering Stroke Severity and Identifying Its Potential Genomic and Proteomic Drivers | Zhenqian Wang, McGill University

12:00 PM | A Catalog of Acute Stroke pQTLs for Acute Drug Target Prioritization | Michael Chong, PhD, Population Health Research Institute

12:15 PM | Panel Discussion and Q&A

12:30 PM | Lunch Buffet

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Session 3: Stroke Subtypes (ICH) and Risk Factors (Intracranial Aneurysms) 

1:30 PM | Multimodal Real-World Data Integration Reveals Interacting Determinants of Intracranial Aneurysm Disease and Outcomes | Philippe Bijlenga, PD, MD-PhD, Geneva University Hospitals

1:45 PM | Cross-Ancestry Genome-Wide Association Studies and Rare Variant Analyses of Intracerebral Hemorrhage | Marie-Gabrielle Duperron, MD, PhD, Brigham and Women’s Hospital

2:00 PM | Large-Scale Plasma Proteomics Reveals Inflammation- and Metabolism-Associated Protein Networks Underlying Ischemic Stroke Risk in Women | Kevin Sánchez, PhD, Brigham and Women’s Hospital

2:15 PM | Genetic Predisposition to Intracranial Aneurysms Is Driven by Vascular Smooth Muscle Cells and Vascular Endothelial Cells | Dennis Maas, University Medical Center Utrecht Brain Center

2:30 PM | Panel Discussion and Q&A

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2:45 PM | Poster Blitz | Chair: Mark Bakker 
15 poster blitz talks (1 minute each)

3:05 PM | Poster Session
Hotel Contessa, Second Floor, Magnolia Meeting Room

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Session 4: Late Breaking Abstracts

3:45 PM | Large Scale Plasma Proteomic Profiling of White Matter Hyperintensity Burden in Ischemic Stroke Patients | Jesper Olsson, The University of Gothenburg, Sweden

4:00 PM | Long-Term Vascular Outcomes and Mortality in CADASIL: A Population-Based Matched Cohort Study | Jay Chol Choi MD, PhD, Jeju National University Hospital, South Korea

4:15 PM | Anticoagulation in Intracerebral Hemorrhage Survivors with Atrial Fibrillation: Multimodal Profiling May Identify Subgroups That are Likely to Benefit | Guido J. Falcone, ScD, MPH, Yale School of Medicine

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Awards and Closing

4:30 PM | Michéle Sale Award
Amy Brodtmann and Brad Worrall

4:40 PM | Michéle Sale Lecture | Stacie Demel, MD, University of Cincinnati

5:00 PM | Closing and Logistics

5:15 PM | Group Photo

5:45 PM | Registered Attendee Reception and Dinner at the Jack Guenther Pavilion at the Briscoe (210 W Market St, San Antonio, TX 78205)

7:45 AM | Conference Check-In Opens | Hotel Contessa, Second-Floor, Ballroom

Attendees are welcome to enjoy a continental breakfast featuring freshly brewed coffee and a selection of hot teas, available in the foyer.

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Keynote Lecture 2

8:15 AM | Biobank-Scale Data & Deep Learning Approaches: Current Perspectives | Sriram Sankararaman, PhD, University of California, Los Angeles

8:45 AM | The Flaws of Others: LLMs and Agentic AI in Biomedical Research | Juan B. Gutiérrez, PhD, The University of Texas at San Antonio

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Session 5: Neuroimaging and Endophenotypes 

9:15 AM | CADISP-Wave-2 Updates – New insights into the genetic determinants of cervical artery dissection by leveraging large biobanks | Quentin Le Grand, PhD, Université de Bordeaux

9:30 AM | The Genetics of Cerebrovascular Structure and Hemodynamics in a Japanese Population: The BRAIN-HEDGE Study | Yoichiro Kamatani, PhD, University of Tokyo

9:45 AM | Deep Learning Analysis of Brain Magnetic Resonance Imaging Doubles the Number of Genomic Risk Loci in Vascular Brain Disease Causing Stroke and Dementia | Bastien Rioux, MD, Paris Brain Institute

10:00 AM | Etiology-Informed WMH Topographies Reveal Expanded Genetic Architecture of Cerebral Small Vessel Disease | Natashia Benjamin, PhD, Barrow Neurological Institute

10:15 AM | Panel Discussion and Q&A

10:30 AM | Break: Morning refreshments and snacks will be available in the foyer.

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Session 6: Rare Variants and Functional Genomics 

10:45 AM | Functional Genomics Analysis of the HNF1A Locus as a Mechanism of Ischemic Stroke in Populations of African Ancestry | Hyacinth Hyacinth, MD, PHD, MPH, FAHA, University of Cincinnati

11:00 AM | Whole-Genome Sequencing Reveals the Cross-Ancestry Genetic Architecture of White Matter Hyperintensity Burden | Janaki Nair Muralidharan, Paris Brain Institute

11:15 AM | Single-Cell RNA Sequencing Identifies an Ischemia-Specific Immune Transcriptome in Human Acute Ischemic Stroke Due to Large Vessel Occlusion | Destiny L. Hooper, MD, Washington University in St. Louis

11:30 AM | Burden of Rare Protein-Coding and Dosage-Sensitive Copy Number Variants and Ischemic Stroke Risk in the Copy Number Variation and Stroke Risk and Outcome Study (CaNVAS) | Kristina Schlicht ,PhD, University Hospital Schleswig Holstein

11:45 AM | Panel Discussion and Q&A

12:00 PM | Lunch Buffet

12:45 PM | Town Hall Meeting and General Assembly [Hybrid]: Including the Epigenetics Working Group Post-Meeting on October 10.

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Session 7: Stroke Outcomes and Recovery 

1:45 PM | GIGAVCID Updates | Bernard Fongang, PhD, UT Health San Antonio

2:00 PM | Vagus Nerve Stimulation Attenuates Monocyte TNF-alpha/NF-kB Signaling After Acute Ischemic Stroke | Isabella Xu, Washington University in St. Louis

2:15 PM | GWAS Meta-Analysis Identifies a Novel Locus of Functional Outcome in East Asian Early-Onset Ischemic Stroke Patients | Jeong-Yoon Lee, MD, Soonchunhyang University Seoul Hospital

2:30 PM | Longitudinal Plasma Brain-Derived Tau Profiles and Associations with Recovery After Acute Ischemic Stroke | Pashtun Shahim, MD, PhD

2:45 PM | Cross-Ancestry Transferability of European-Derived Drug-Response Polygenic Scores in Korean Young-Onset Ischemic Stroke: Results from the GENE_YAS Study | Eung-Joon Lee, MD, Seoul National University Hospital

3:00 PM | Panel Discussion and Q&A

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3:15 PM | Poster Blitz | Chair: Mark Bakker
15 poster blitz talks (1 minute each)

3:30 PM | Poster Session
Hotel Contessa, Second Floor, Magnolia Meeting Room

Join colleagues for poster presentations while enjoying afternoon refreshments and snacks.

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Session 8: Additional Mentions

4:15 PM | Molecular Biomarkers in Stroke Recovery: Consensus-Based Core Recommendations from the Fourth Stroke Recovery and Rehabilitation Roundtable | Arne Lindgren, MD, Lund University

4:30 PM | Multi Ancestry GWAS Meta-Analysis of Delirium (Discovery Phase) | Michael Chong, PhD, Population Health Research Institute, CRLB-GMEL

4:45 PM | Website Maintenance | Qi Chang Lin, University Medical Center Utrecht

ECR Committee Updates | Chad Aldridge, DPT, University of Virginia

5:00 PM | Announcement from the Next Host, Final Logistics and Closing Remarks

5:40 PM | Registered Attendee Dinner Cruise on San Antonio’s Historic River Walk

• Please plan to meet on the Riverwalk at the River Level entrance of Hotel Contessa for a prompt 5:40 PM departure.
• Please note that seating has been assigned in advance, and meal selections were pre-arranged based on your registration choices. Event staff will be available to assist you with seating upon boarding.
•  Limited seats remain available. If you have not yet registered for the dinner cruise, please contact Norene Casas as soon as possible to inquire about availability.

8:00–11:00 AM | Post-Meeting Working Groups at Hotel Contessa

Working Group 1: Epigenetics | River Level, Cypress Meeting Room
Joan Jiménez-Balado, PhD, and Cristina Gallego-Fabrega, PhD

Working Group 2: Translation / Clinical Trials | Street Level, Anaqua Meeting Room
Organizer TBD

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Suggested Self-Guided Tours of San Antonio
For attendees interested in exploring San Antonio, several self-guided tour options are available throughout the city. All tours and admission fees are self-pay.

The Alamo
One of Texas’ most iconic historic landmarks, The Alamo offers a variety of guided and self-guided experiences that explore the history of the 1836 Battle of the Alamo and the people who shaped Texas history. Please note that food and beverage service is not available at The Alamo tour site, so we recommend enjoying lunch before beginning your excursion

🔗 Explore The Alamo Tours and Experiences

Historic Market Square (El Mercado)
Visit the largest Mexican market in the United States, featuring local artisans, specialty shops and vibrant cultural attractions. Market Square is an excellent destination for shopping and experiencing San Antonio’s rich heritage.

San Fernando Cathedral & Main Plaza
Explore one of the oldest cathedrals in the United States and enjoy the surrounding Main Plaza area, known for its historic significance and beautiful architecture.

The Pearl District
A revitalized historic brewery complex featuring boutique shopping, local restaurants, public art and green spaces. The Pearl is a popular destination for visitors seeking a modern San Antonio experience.

San Antonio Missions National Historical Park
A UNESCO World Heritage Site, the Missions offer visitors the opportunity to explore four beautifully preserved Spanish colonial missions and learn about the region’s cultural history.

🔗 San Antonio Missions Tour (3.5 hours)

All activities are optional and at the attendee’s own expense. Transportation and admission fees, where applicable, are the responsibility of each participant.