Pre-Meeting Working Groups at Hotel Contessa

 12:00–2:00 PM | Pre-Meeting 1: ISGC Early Career Working Group (WG)
Mark Bakker, PhD

 2:00–4:00 PM | Pre-Meeting 2: Copy Number Variation and Stroke Risk and Outcome Study (CaNVAS)
John W. Cole, MD, MS

 2:00–5:00 PM | Pre-Meeting 3: Global Alliance Outcomes
Arne Lindgren, MD, PhD

Steering Committee Dinner

8:00 AM | Conference Check-In Opens | Hotel Contessa, Second-Floor

Continental Breakfast Featuring Freshly Brewed Coffee and Assorted Hot Teas

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8:45 AM | Welcome and Opening Remarks | Sudha Seshadri, MD, and Muralidharan Sargurupremraj, PhD

Introduction to the ISGC | Amy Brodtmann, MBBS, PRACP, PhD, FANZAN, and Brad Worrall, MD, MSc

9:00 AM | Keynote Lecture 1

Stroke Genomics: From Discovery to Clinical Translation | Stéphanie Debette, MD, Paris Brain Institute

Application of AI/ML in Multi-omics Integration, Harmonization and Discovery | Zhongming Zhao, PhD, MS, UTHealth Houston

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Session 1: Genetic Architecture of Stroke and Its Subtypes 

10:10 AM |TERASTROKE GWAS: Consortium Update | Rainer Malik, PhD, Stéphanie Debette, Martin Dichgans, MD

10:30 AM | Genetic Underpinnings of Stroke in Hispanic/Latino Populations | Yao Tu, PhD, Penn State University

10:45 AM | Modifying Effects of Polygenic Risk Scores in Monogenic Cerebral Small Vessel Disease | Shiyao Cheng, MPH, Paris Brain Institute

11:00 AM | Panel Discussion and Q&A

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Session 2: xQTL/pQTL & Drug-Target Discovery 

11:15 AM | Multi-Scale Genomic Triangulation of Druggable Targets for Neuroimaging Markers of cSVD Identifies Therapeutic Candidates and Pharmacogenomic Modifiers | Muralidharan Sargurupremraj, PhD, UT Health San Antonio

11:30 AM | Proteogenomic Integration Reveals Paralemmin-1 as a Mediator of Increased Intracerebral Hemorrhage Risk in APOE ε4 Carriers | Shufan Huo, MD, PhD, German Center For Neurodegenerative Diseases

11:45 AM |  A Multi-Omics Tree-Based Framework for Clustering Stroke Severity and Identifying Its Potential Genomic and Proteomic Drivers | Zhenqian Wang, McGill University

12:00 PM | A Catalog of Acute Stroke pQTLs for Acute Drug Target Prioritization | Michael Chong, PhD, University of Montreal 

12:15 PM | Panel Discussion and Q&A

12:30 PM | Lunch Buffet

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Session 3: Stroke Subtypes (ICH) and Risk Factors (Intracranial Aneurysms) 

1:30 PM | Multimodal Real-World Data Integration Reveals Interacting Determinants of Intracranial Aneurysm Disease and Outcomes | Philippe Bijlenga, PD, MD-PhD, Geneva University Hospitals

2:00 PM | Cross-Ancestry Genome-Wide Association Studies and Rare Variant Analyses of Intracerebral Hemorrhage | Marie-Gabrielle Duperron, MD, PhD, Brigham and Women’s Hospital

2:15 PM |  Large-Scale Plasma Proteomics Reveals Inflammation- and Metabolism-Associated Protein Networks Underlying Ischemic Stroke Risk in Women | Kevin Sánchez, PhD, Brigham and Women’s Hospital

2:30 PM |  Genetic Predisposition to Intracranial Aneurysms Is Driven by Vascular Smooth Muscle Cells and Vascular Endothelial Cells | Dennis Maas, University Medical Center Utrecht Brain Center

2:45 PM | Panel Discussion and Q&A

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3:00 PM | Poster Blitz | Chair: Mark Bakker 
15 poster blitz talks (1 minute each)

3:20 PM | Poster Session
Hotel Contessa, Second Floor, Magnolia Meeting Room

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Session 4: New Horizon Lecture 

4:00 PM | A Bug or a Feature? Lessons from Real-World, Large-Scale Stroke Image Analysis | Natalia S. Rost, MD, MPH, FAAN, FAHA,  Massachusetts General Hospital

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Awards and Closing

4:30 PM | Mitchell Sale Award
Amy Brodtmann and Brad Worrall

4:45 PM | Closing and Logistics

 5:45 PM | Registered Attendee Reception and Dinner on San Antonio’s Historic River Walk

8:30 AM | Conference Check-In Opens | Hotel Contessa, Second-Floor

Continental Breakfast Featuring Freshly Brewed Coffee and Assorted Hot Teas

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9:00 AM | Keynote Lecture 2

Biobank-Scale Data & Deep Learning Approaches: Current Perspectives | Sriram Sankararaman, PhD, University of California, Los Angeles

The Flaws of Others: LLMs and Agentic AI in Biomedical Research | Juan B. Gutiérrez, PhD, The University of Texas at San Antonio

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Session 5: Neuroimaging and Endophenotypes 

10:10 AM | Scalable AI and Harmonized Neuroimaging Techniques | Mohamad Habes, PhD, UT Health San Antonio

10:30 AM | The Genetics of Cerebrovascular Structure and Hemodynamics in a Japanese Population: The BRAIN-HEDGE Study | Yoichiro Kamatani, PhD, University of Tokyo

10:45 AM | Deep Learning Analysis of Brain Magnetic Resonance Imaging Doubles the Number of Genomic Risk Loci in Vascular Brain Disease Causing Stroke and Dementia | Bastien Rioux, MD, Paris Brain Institute

11:00 AM | Etiology-Informed WMH Topographies Reveal Expanded Genetic Architecture of Cerebral Small Vessel Disease | Chia-Ling Phuah, MD, MMSc, Barrow Neurological Institute

11:15 AM | Panel Discussion and Q&A

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Session 6: Rare Variants and Functional Genomics 

11:30 AM | Functional Genomics Analysis of the HNF1A Locus as a Mechanism of Ischemic Stroke in Populations of African Ancestry | Hyacinth Hyacinth, MD, PHD, MPH, FAHA, University of Cincinnati

11:45 AM | Whole-Genome Sequencing Reveals the Cross-Ancestry Genetic Architecture of White Matter Hyperintensity Burden | Janaki Nair Muralidharan, Paris Brain Institute

12:00 PM | Single-Cell RNA Sequencing Identifies an Ischemia-Specific Immune Transcriptome in Human Acute Ischemic Stroke Due to Large Vessel Occlusion | Destiny L. Hooper, MD, Washington University in St. Louis

12:15 PM | Burden of Rare Protein-Coding and Dosage-Sensitive Copy Number Variants and Ischemic Stroke Risk in the Copy Number Variation and Stroke Risk and Outcome Study (CaNVAS) | Kristina Schlicht ,PhD, University Hospital Schleswig Holstein

12:15 PM | Panel Discussion and Q&A

12:45 PM | Lunch Buffet

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Session 7: Stroke Outcomes and Recovery 

1:30 PM | GIGAVCID Updates | Bernard Fongang, PhD, UT Health San Antonio

1:45 PM | Vagus Nerve Stimulation Attenuates Monocyte TNF-alpha/NF-kB Signaling After Acute Ischemic Stroke | Isabella Xu, Washington University in St. Louis

2:15 PM | Longitudinal Plasma Brain-Derived Tau Profiles and Associations with Recovery After Acute Ischemic Stroke | Pashtun Shahim, MD, PhD

2:30 PM | Cross-Ancestry Transferability of European-Derived Drug-Response Polygenic Scores in Korean Young-Onset Ischemic Stroke: Results from the GENE_YAS Study | Eung-Joon Lee, MD, Seoul National University Hospital

2:45 PM | Panel Discussion and Q&A

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3:00 PM | Poster Blitz | Chair: Mark Bakker 
15 poster blitz talks (1 minute each)

3:20 PM | Poster Session
Hotel Contessa, Second Floor, Magnolia Meeting Room

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4:00 PM | Website Maintenance and ECR Committee Updates | Mark Bakker

4:30 PM | Open Discussion

5:00 PM | Announcement from the Next Host, Final Logistics, and Closing Remarks

5:30 PM | Registered Attendee Reception and Dinner on San Antonio’s Historic River Walk